What do you get when you cross characters a la Hellsing with the crazy quirkiness of a series like Gurren Lagann?
The answer could be described as Needless.
In World War Three, Japan was hit by a huge bomb by an unknown assailant. A large crater was formed from it and called The Black Spot. After the war there wasn't a whole lot left of humankind. Over time, mutants were known to be appearing around the area of The Black Spot. These mutants look like everyone else but have extraordinary abilities and because of this they are frowned upon by society and are called Needless. (Sounds like I just similary described the X-men. O_o )
Even though I'm only about seven episodes in, so far it's been a great ride. Fun characters with enjoyable personalities. While this could've been done as a very serious story, it does quite the opposite and doesn't take itself overly serious at all - and the formula works. There's been some good laughs to be had.